Lymphovenous hemostasis and the role of platelets in regulating lymphatic flow and lymphatic vessel maturation.
Identifieur interne : 000E34 ( Main/Exploration ); précédent : 000E33; suivant : 000E35Lymphovenous hemostasis and the role of platelets in regulating lymphatic flow and lymphatic vessel maturation.
Auteurs : John D. Welsh [États-Unis] ; Mark L. Kahn [États-Unis] ; Daniel T. Sweet [États-Unis]Source :
- Blood [ 1528-0020 ] ; 2016.
Descripteurs français
- KwdFr :
- Activation plaquettaire, Animaux, Chylothorax (anatomopathologie), Chylothorax (métabolisme), Chylothorax (physiopathologie), Glycoprotéines membranaires (métabolisme), Humains, Lectines de type C (métabolisme), Lymphoedème (anatomopathologie), Lymphoedème (métabolisme), Lymphoedème (physiopathologie), Plaquettes (anatomopathologie), Plaquettes (métabolisme), Souris, Thrombose (anatomopathologie), Thrombose (métabolisme), Vaisseaux lymphatiques (anatomopathologie), Vaisseaux lymphatiques (métabolisme).
- MESH :
- anatomopathologie : Chylothorax, Lymphoedème, Plaquettes, Thrombose, Vaisseaux lymphatiques.
- métabolisme : Chylothorax, Glycoprotéines membranaires, Lectines de type C, Lymphoedème, Plaquettes, Thrombose, Vaisseaux lymphatiques.
- physiopathologie : Chylothorax, Lymphoedème.
- Activation plaquettaire, Animaux, Humains, Souris.
English descriptors
- KwdEn :
- Animals, Blood Platelets (metabolism), Blood Platelets (pathology), Chylothorax (metabolism), Chylothorax (pathology), Chylothorax (physiopathology), Humans, Lectins, C-Type (metabolism), Lymphatic Vessels (metabolism), Lymphatic Vessels (pathology), Lymphedema (metabolism), Lymphedema (pathology), Lymphedema (physiopathology), Membrane Glycoproteins (metabolism), Mice, Platelet Activation, Thrombosis (metabolism), Thrombosis (pathology).
- MESH :
- chemical , metabolism : Lectins, C-Type, Membrane Glycoproteins.
- metabolism : Blood Platelets, Chylothorax, Lymphatic Vessels, Lymphedema, Thrombosis.
- pathology : Blood Platelets, Chylothorax, Lymphatic Vessels, Lymphedema, Thrombosis.
- physiopathology : Chylothorax, Lymphedema.
- Animals, Humans, Mice, Platelet Activation.
Abstract
Aside from the established role for platelets in regulating hemostasis and thrombosis, recent research has revealed a discrete role for platelets in the separation of the blood and lymphatic vascular systems. Platelets are activated by interaction with lymphatic endothelial cells at the lymphovenous junction, the site in the body where the lymphatic system drains into the blood vascular system, resulting in a platelet plug that, with the lymphovenous valve, prevents blood from entering the lymphatic circulation. This process, known as "lymphovenous hemostasis," is mediated by activation of platelet CLEC-2 receptors by the transmembrane ligand podoplanin expressed by lymphatic endothelial cells. Lymphovenous hemostasis is required for normal lymph flow, and mice deficient in lymphovenous hemostasis exhibit lymphedema and sometimes chylothorax phenotypes indicative of lymphatic insufficiency. Unexpectedly, the loss of lymph flow in these mice causes defects in maturation of collecting lymphatic vessels and lymphatic valve formation, uncovering an important role for fluid flow in driving endothelial cell signaling during development of collecting lymphatics. This article summarizes the current understanding of lymphovenous hemostasis and its effect on lymphatic vessel maturation and synthesizes the outstanding questions in the field, with relationship to human disease.
DOI: 10.1182/blood-2016-04-636415
PubMed: 27385789
Affiliations:
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Le document en format XML
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Kahn</name><affiliation wicri:level="2"><nlm:affiliation>Department of Medicine and Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Medicine and Cardiovascular Institute, University of Pennsylvania, Philadelphia</wicri:cityArea></affiliation></author><author><name sortKey="Sweet, Daniel T" sort="Sweet, Daniel T" uniqKey="Sweet D" first="Daniel T" last="Sweet">Daniel T. Sweet</name><affiliation wicri:level="2"><nlm:affiliation>Department of Medicine and Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Medicine and Cardiovascular Institute, University of Pennsylvania, Philadelphia</wicri:cityArea></affiliation></author></analytic><series><title level="j">Blood</title><idno type="eISSN">1528-0020</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Blood Platelets (metabolism)</term><term>Blood Platelets (pathology)</term><term>Chylothorax (metabolism)</term><term>Chylothorax (pathology)</term><term>Chylothorax (physiopathology)</term><term>Humans</term><term>Lectins, C-Type (metabolism)</term><term>Lymphatic Vessels (metabolism)</term><term>Lymphatic Vessels (pathology)</term><term>Lymphedema (metabolism)</term><term>Lymphedema (pathology)</term><term>Lymphedema (physiopathology)</term><term>Membrane Glycoproteins (metabolism)</term><term>Mice</term><term>Platelet Activation</term><term>Thrombosis (metabolism)</term><term>Thrombosis (pathology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Activation plaquettaire</term><term>Animaux</term><term>Chylothorax (anatomopathologie)</term><term>Chylothorax (métabolisme)</term><term>Chylothorax (physiopathologie)</term><term>Glycoprotéines membranaires (métabolisme)</term><term>Humains</term><term>Lectines de type C (métabolisme)</term><term>Lymphoedème (anatomopathologie)</term><term>Lymphoedème (métabolisme)</term><term>Lymphoedème (physiopathologie)</term><term>Plaquettes (anatomopathologie)</term><term>Plaquettes (métabolisme)</term><term>Souris</term><term>Thrombose (anatomopathologie)</term><term>Thrombose (métabolisme)</term><term>Vaisseaux lymphatiques (anatomopathologie)</term><term>Vaisseaux lymphatiques (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Lectins, C-Type</term><term>Membrane Glycoproteins</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Chylothorax</term><term>Lymphoedème</term><term>Plaquettes</term><term>Thrombose</term><term>Vaisseaux lymphatiques</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Blood Platelets</term><term>Chylothorax</term><term>Lymphatic Vessels</term><term>Lymphedema</term><term>Thrombosis</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Chylothorax</term><term>Glycoprotéines membranaires</term><term>Lectines de type C</term><term>Lymphoedème</term><term>Plaquettes</term><term>Thrombose</term><term>Vaisseaux lymphatiques</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Blood Platelets</term><term>Chylothorax</term><term>Lymphatic Vessels</term><term>Lymphedema</term><term>Thrombosis</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Chylothorax</term><term>Lymphoedème</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Chylothorax</term><term>Lymphedema</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Humans</term><term>Mice</term><term>Platelet Activation</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Activation plaquettaire</term><term>Animaux</term><term>Humains</term><term>Souris</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Aside from the established role for platelets in regulating hemostasis and thrombosis, recent research has revealed a discrete role for platelets in the separation of the blood and lymphatic vascular systems. Platelets are activated by interaction with lymphatic endothelial cells at the lymphovenous junction, the site in the body where the lymphatic system drains into the blood vascular system, resulting in a platelet plug that, with the lymphovenous valve, prevents blood from entering the lymphatic circulation. This process, known as "lymphovenous hemostasis," is mediated by activation of platelet CLEC-2 receptors by the transmembrane ligand podoplanin expressed by lymphatic endothelial cells. Lymphovenous hemostasis is required for normal lymph flow, and mice deficient in lymphovenous hemostasis exhibit lymphedema and sometimes chylothorax phenotypes indicative of lymphatic insufficiency. Unexpectedly, the loss of lymph flow in these mice causes defects in maturation of collecting lymphatic vessels and lymphatic valve formation, uncovering an important role for fluid flow in driving endothelial cell signaling during development of collecting lymphatics. This article summarizes the current understanding of lymphovenous hemostasis and its effect on lymphatic vessel maturation and synthesizes the outstanding questions in the field, with relationship to human disease.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Pennsylvanie</li></region></list><tree><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Welsh, John D" sort="Welsh, John D" uniqKey="Welsh J" first="John D" last="Welsh">John D. Welsh</name></region><name sortKey="Kahn, Mark L" sort="Kahn, Mark L" uniqKey="Kahn M" first="Mark L" last="Kahn">Mark L. Kahn</name><name sortKey="Sweet, Daniel T" sort="Sweet, Daniel T" uniqKey="Sweet D" first="Daniel T" last="Sweet">Daniel T. Sweet</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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